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MicroRNA and mRNA integrated network analysis

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    MicroRNAs are a class of small RNA molecules present in eukaryotes that are known to be highly conserved. They have been found to control gene expression by binding to its target mRNA by virtue of the sequence complementarity between the miRNA seed region and the mature mRNA sequence. MiRNAs have been implicated in various diseases, and most importantly, in various types of cancer. Therefore, analyzing the expression of different miRNAs and the target mRNAs of the multitude of proteins they regulate may help in identifying biomarkers and potential tumor suppressors. Using chromatin modifying drugs to activate tumor suppressor miRNAs can regulate target oncogenes, and it may lead to novel cancer therapies in the future. miRNAs can complement other genomic and proteomic biomarkers for cancer diagnosis and prognosis.



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