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    Introduction

    MicroRNAs are a class of small RNA molecules present in eukaryotes that are known to be highly conserved. They have been found to control gene expression by binding to its target mRNA by virtue of the sequence complementarity between the miRNA seed region and the mature mRNA sequence. MiRNAs have been implicated in various diseases, and most importantly, in various types of cancer. Therefore, analyzing the expression of different miRNAs and the target mRNAs of the multitude of proteins they regulate may help in identifying biomarkers and potential tumor suppressors. Using chromatin modifying drugs to activate tumor suppressor miRNAs can regulate target oncogenes, and it may lead to novel cancer therapies in the future. miRNAs can complement other genomic and proteomic biomarkers for cancer diagnosis and prognosis.

     

    Reading

    Tseng, C. W., C. C. Lin, et al. (2011). "Integrative network analysis reveals active microRNAs and their functions in gastric cancer." BMC Syst Biol 5: 99. (PDF)

     

    Bibiliography

    Cho, W. C. (2007). "OncomiRs: the discovery and progress of microRNAs in cancers." Mol Cancer 6: 60. (PDF)

    Guo, S. L., Z. Peng, et al. (2011). "miR-148a promoted cell proliferation by targeting p27 in gastric cancer cells." Int J Biol Sci 7(5): 567-574. (PDF)

    Nam, S., M. Li, et al. (2009). "MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression." Nucleic Acids Res 37(Web Server issue): W356-362. (PDF)

    Philippidou, D., M. Schmitt, et al. (2010). "Signatures of microRNAs and selected microRNA target genes in human melanoma." Cancer Res 70(10): 4163-4173. (PDF)

    Sarver, A. L., L. Li, et al. (2010). "MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration." Cancer Res 70(23): 9570-9580. (PDF)

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