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    Introduction

    Reading Assigment

    1. Munger, J. et al. (2008) Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat. Biotechnol. 26 (10): 1179-1186 pdf

    (3/19 updated pdf link to final version of manuscript)

    *Supplemental Information pdf
     

    Related Reading

    Background

    2. Baker, M. (2011) Metabolomics: from small molecules to big ideas. Nature 8 (2):117-121 pdf

    3. Kell, D.B. (2004) Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol. 7:296-307 pdf

    4. Zamboni, N. (2011) 13C metabolic flux analysis in complex systems. Curr Opin Biotechnol. 22:103-8 pdf

    Theory and Application

    5. Ravasz, E. et al. (Barabasi Lab) (2002) Hierarchical Organization of Modularity in Metabolic Networks. Science 297(5586):1551-5  pdf

    6. Durek, P. and Walther, D. (2008) The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principle. BMC Systems Biol. 2(100) pdf

    7. Lee, D.-S. et al. (Barabasi Lab) (2008) The implications of human metabolic network topology for disease comorbidity. PNAS 105 (29):9880-9885  pdf

    8. Motter et al. (Barabasi Lab) (2008) Predicting synthetic rescues in metabolic networks. Molecular Systems Biology. 4:168 pdf

    9. Li, X. et al. (2010) Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses. Cell. 143:639-650. pdf

    10. Kell, D.B. (2006) Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discovery Today. 11(23/24):1085-1092. pdf

    11. Sweetlove, L.J. et al. (2003) Predictive Metabolic Engineering: A Goal for Systems Biology. Plant Physiol. 132:420-5. pdf

    12. Aho, T. et al. (2010) Reconstruction and Validation of RefRec: A Global Model for the Yeast Molecular Interaction Network. PLoS ONE 5(5): e10662. html

    Computational Resources

    12. Kamburov et al. (2011) Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA. Bioinformatics 27(20):2917-8 pdf

    13. Schmidt, M.D. et al. (2011) Automated refinement and inference of analytical models for metabolic networks. Phys. Biol. 8 pdf

    14. KEGG Pathway Database

    See reference (2) for more metabolomics tools. 

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